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Plague is a disease that requires reporting to the Centers for Disease Control and Prevention (CDC) due to its potential to cause significant outbreaks and its public health implications. Plague, caused by the bacterium Yersinia pestis, can be transmitted to humans through flea bites, exposure to infected animals, or respiratory droplets. Its severity and the possibility of person-to-person transmission in certain forms, such as pneumonic plague, necessitate surveillance and intervention strategies to control outbreaks and protect public health.

In contrast, while measles and mumps also have reporting requirements due to their communicability and associated health risks, they are categorized differently in terms of epidemiological focus compared to plague. Impetigo, on the other hand, is a common bacterial skin infection that, although infectious, does not typically require the same level of reporting or monitoring as plague. Therefore, plague is uniquely significant in the context of public health reporting to the CDC.